HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: JIP2 (Q13387)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: MAPK8IP2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 824
+	Hs
		338374 EGFR_HUMAN (16-1253): 0: 1070: 48.40		JIP2_HUMAN (1-824): 9.09e-151: 464: 100.00
+	Hs
		383867 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1B_HUMAN (536-809): 1.38e-53: 204: 15.88
+	Hs
		383908 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1A_HUMAN (215-809): 4.34e-51: 196: 13.93
+	Hs
		383583 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MUC1_HUMAN (133-667): 1.27e-26: 119: 10.64
+	Hs
		384031 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		JIP1_HUMAN (13-351): 1.71e-16: 86: 18.75
+	Hs
		383851 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS2_HUMAN (105-502): 5.26e-10: 65.4: 17.16
+	Hs
		1070979 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1B_HUMAN (536-809): 1.38e-53: 204: 15.88
+	Hs
		1070992 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1A_HUMAN (215-809): 4.34e-51: 196: 13.93
+	Hs
		338632 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANS1B_HUMAN (536-809): 1.38e-53: 204: 15.88
+	Hs
		338786 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANS1A_HUMAN (215-809): 4.34e-51: 196: 13.93
+	Hs
		338620 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MICA3_HUMAN (23-631): 7.8e-36: 149: 12.64
+	Hs
		554307 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC1_HUMAN (133-667): 1.27e-26: 119: 10.64
+	Hs
		338633 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SH3R1_HUMAN (59-663): 1.98e-29: 128: 12.93
+	Hs
		337875 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC1_HUMAN (133-667): 1.27e-26: 119: 10.64
+	Hs
		1070974 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		TENS2_HUMAN (105-502): 5.26e-10: 65.4: 17.16
+	Hs
		554266 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		MUC1_HUMAN (133-667): 1.27e-26: 119: 10.64
+	Hs
		339153 EGFR_HUMAN (16-1253): 0: 1070: 48.40		JIP1_HUMAN (13-351): 1.71e-16: 86: 18.75
+	Hs
		338550 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TENS2_HUMAN (105-502): 5.26e-10: 65.4: 17.16
+	Hs
		601934 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		TENS2_HUMAN (105-502): 5.26e-10: 65.4: 17.16
+	Mm
		1206693 FAK2_MOUSE (707-1006): 9.29e-54: 207: 36.42		ANS1B_MOUSE (519-809): 2.07e-50: 194: 17.01