HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: DSG2 (Q14126)
Desmoglein-2 (Cadherin family member 5) (HDGC)
Gene: DSG2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	34591612
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1118
+	Hs
		338415 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		383569 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Cl
		94520 ERBB2_CANLF (1-1255): 0: 1278: 92.22		CADH1_CANLF (30-670): 0: 572: 30.64
+	Hs
		337849 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		521720 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		1048589 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		872645 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		383600 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		339196 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PCDB3_HUMAN (57-599): 1.32e-84: 293: 18.34
+	Xl
		292720 Q153D8_XENLA (1-1252): 0: 1050: 57.22		O93264_XENLA (1-493): 2.12e-78: 276: 18.63
+	Hs
		337911 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		339197 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PCDBB_HUMAN (1-392): 8.44e-52: 198: 16.92
+	Hs
		338302 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		521744 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		434134 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		434321 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		PCDGH_HUMAN (1-387): 8.41e-62: 230: 20.45
+	Hs
		580236 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		580213 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		971014 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		872632 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90