HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SEPT6 (Q14141)
Septin-6
Gene: SEPTIN6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 434
+	Hs
		383907 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Hs
		338417 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SEPT6_HUMAN (1-434): 0: 607: 100.00
+	Hs
		338779 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Hs
		339064 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SEP10_HUMAN (12-431): 0: 573: 71.67
+	Hs
		339093 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SEPT9_HUMAN (9-323): 2.65e-152: 445: 39.94
+	Hs
		339089 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SEPT3_HUMAN (7-307): 1.89e-152: 437: 40.45
+	Hs
		434254 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Hs
		665599 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		SEPT6_HUMAN (1-434): 0: 607: 100.00
+	Hs
		1048994 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		SEPT6_HUMAN (1-434): 0: 607: 100.00
+	Hs
		665639 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Hs
		665674 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		SEP10_HUMAN (12-431): 0: 573: 71.67
+	Hs
		411459 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Hs
		665678 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		SEPT9_HUMAN (9-323): 2.65e-152: 445: 39.94
+	Hs
		665677 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		SEPT3_HUMAN (7-307): 1.89e-152: 437: 40.45
+	Hs
		872441 EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46		SEPT6_HUMAN (1-434): 0: 607: 100.00
+	Hs
		872498 EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46		SEP10_HUMAN (12-431): 0: 573: 71.67
+	Hs
		435638 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		SEPT6_HUMAN (1-434): 0: 607: 100.00
+	Hs
		435711 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		SEPT8_HUMAN (1-427): 0: 581: 76.22
+	Hs
		435787 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		SEP10_HUMAN (12-431): 0: 573: 71.67