HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0010008 - endosome membrane GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 540
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (100-534): 8.93e-99: 319: 16.35
+	Hs
		383705 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV2_HUMAN (113-534): 1.29e-83: 279: 16.40
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (237-536): 1.06e-53: 193: 14.25
+	Hs
		383601 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (364-535): 2.53e-44: 165: 22.10
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		383704 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BMX_HUMAN (237-539): 4.7e-41: 159: 13.51
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (376-537): 4.64e-41: 157: 20.59
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (376-538): 4.56e-41: 157: 20.47
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (402-535): 2.31e-40: 155: 22.14
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (368-536): 2.84e-40: 154: 20.79
+	Hs
		383670 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MATK_HUMAN (399-531): 2.04e-35: 140: 28.89
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (388-530): 8.19e-32: 132: 30.07
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (398-533): 1.07e-30: 126: 28.26
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (417-523): 3.05e-23: 105: 28.97
+	Hs
		275161 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRAP2_HUMAN (375-523): 4.52e-24: 104: 23.49
+	Hs
		383762 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		383629 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		383633 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79