HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: DHB12 (Q53GQ0)
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)
Gene: HSD17B12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 312
+	Hs
		383657 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DHB3_HUMAN (15-296): 6.66e-72: 226: 41.70
+	Hs
		338515 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00
+	Hs
		338368 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DHRS2_HUMAN (48-302): 7.48e-75: 232: 22.57
+	Hs
		338559 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DRS7B_HUMAN (54-240): 6.84e-16: 78.6: 29.23
+	Hs
		435661 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00
+	Rn
		88679 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		D3ZPU3_RAT (1-312): 4.67e-89: 270: 78.85
+	Rn
		544934 INSR_RAT (357-634): 2.53e-16: 87.2: 19.87		PECR_RAT (38-300): 2.51e-71: 224: 19.33