HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: H90B2 (Q58FF8)
Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)
Gene: HSP90AB2P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 381
+	Hs
		383576 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ENPL_HUMAN (185-381): 1.31e-65: 224: 34.98
+	Hs
		338519 EGFR_HUMAN (16-1253): 0: 1070: 48.40		H90B3_HUMAN (1-381): 8.64e-116: 350: 59.04
+	Hs
		383857 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		Q6PK50_HUMAN (109-251): 1.1e-33: 130: 87.41
+	Hs
		383544 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		383537 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Rn
		948940 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		HS90A_RAT (87-251): 1.57e-26: 113: 59.41
+	Hs
		337864 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ENPL_HUMAN (185-381): 1.31e-65: 224: 34.98
+	Rn
		948941 Q9QX70_RAT (21-1254): 0: 1116: 48.96		HS90A_RAT (87-251): 1.57e-26: 113: 59.41
+	Hs
		438189 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		431871 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		338573 EGFR_HUMAN (16-1253): 0: 1070: 48.40		Q6PK50_HUMAN (109-251): 1.1e-33: 130: 87.41
+	Hs
		337799 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		337788 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		437893 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		431532 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		238334 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		238331 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		431435 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54
+	Hs
		438028 EPHB1_HUMAN (644-1077): 3.21e-126: 415: 28.54		HS90B_HUMAN (109-251): 8.66e-32: 128: 87.41
+	Hs
		431691 EPHB1_HUMAN (644-1077): 3.21e-126: 415: 28.54		HS90A_HUMAN (87-251): 2.97e-26: 112: 61.54