HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	30898150
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 422
+	Hs
		383711 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB1_HUMAN (5-417): 7.24e-127: 391: 19.38
+	Hs
		383562 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		383608 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR3_HUMAN (10-409): 1.6e-125: 383: 27.01
+	Hs
		383605 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64
+	Hs
		383631 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA3_HUMAN (2-408): 7.62e-122: 378: 20.49
+	Hs
		383630 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		383710 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		383632 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		383540 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		383712 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		383607 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (90-390): 9.56e-110: 334: 28.95
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (90-390): 9.29e-110: 334: 28.95
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (143-381): 3.74e-40: 155: 36.63
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89
+	Hs
		383752 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TIE2_HUMAN (146-380): 2.39e-34: 137: 31.56