HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0008284 - positive regulation of cell population proliferation GO:0030971 - receptor tyrosine kinase binding GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 630
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		383905 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC3_HUMAN (24-621): 5.09e-140: 422: 42.88
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (81-620): 1.11e-123: 379: 38.57
+	Hs
		383853 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS3_HUMAN (21-611): 4.44e-92: 312: 12.20
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (341-629): 8.51e-51: 190: 19.52
+	Hs
		383867 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1B_HUMAN (64-380): 2.43e-48: 184: 16.77
+	Hs
		145964 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2B2_HUMAN (339-622): 5.86e-49: 182: 19.80
+	Hs
		383862 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2D5_HUMAN (262-613): 1.25e-50: 182: 15.15
+	Hs
		383908 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1A_HUMAN (63-411): 2.17e-45: 175: 16.52
+	Hs
		383882 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2D3_HUMAN (331-619): 2.9e-45: 174: 17.16
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		383823 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHB_HUMAN (356-617): 5.99e-44: 166: 20.73
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (367-628): 2.22e-43: 165: 16.12
+	Hs
		383533 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FES_HUMAN (384-629): 4.9e-42: 164: 20.16
+	Hs
		275523 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BCAR3_HUMAN (375-619): 1.73e-41: 163: 19.25
+	Hs
		383591 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG2_HUMAN (269-630): 5.78e-40: 159: 13.88
+	Hs
		208972 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		383587 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		383629 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48