HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0032587 - ruffle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 860
+	Hs
		275523 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (112-393): 2.09e-58: 210: 14.29
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (86-569): 1.39e-54: 205: 14.90
+	Hs
		383533 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FES_HUMAN (1-394): 3.67e-54: 204: 18.75
+	Hs
		383704 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BMX_HUMAN (15-393): 6.23e-54: 200: 12.64
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (108-394): 1.28e-54: 199: 13.44
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		383684 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Hs
		383685 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRKL_HUMAN (220-480): 2.1e-51: 184: 18.12
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (97-322): 5.53e-44: 170: 24.02
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (112-321): 2.18e-33: 138: 18.94
+	Hs
		383601 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG1_HUMAN (105-427): 7.42e-27: 120: 14.37
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (214-310): 1.18e-27: 113: 27.00
+	Hs
		208972 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72
+	Hs
		383629 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58