HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 649
+	Hs
		338742 EGFR_HUMAN (16-1253): 0: 1070: 48.40		UBS3B_HUMAN (1-649): 0: 1066: 100.00
+	Hs
		338203 EGFR_HUMAN (16-1253): 0: 1070: 48.40		UBS3A_HUMAN (12-643): 0: 947: 43.37
+	Mm
		1143571 JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53		UBS3B_MOUSE (12-649): 0: 1037: 97.65
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		383923 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Mm
		964559 EGFR_MOUSE (17-1254): 0: 1126: 48.48		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Rn
		924998 Q9QX70_RAT (21-1254): 0: 1116: 48.96		GRB2_RAT (156-319): 1.37e-45: 163: 21.56
+	Hs
		924589 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		338251 EGFR_HUMAN (16-1253): 0: 1070: 48.40		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		601876 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		338817 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		298945 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		338935 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SRBS1_HUMAN (258-317): 1.89e-18: 92.2: 40.00
+	Hs
		338633 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SH3R1_HUMAN (216-315): 3.02e-18: 91.4: 28.00
+	Hs
		238395 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		434170 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		872610 EPHB1_HUMAN (644-1077): 3.21e-126: 415: 28.54		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		665574 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		872621 EPHB2_MOUSE (648-1056): 3.84e-123: 407: 31.00		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		665643 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00