HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070372 - regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 223
+	Hs
		304905 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		383901 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SSH1_HUMAN (10-201): 8.62e-56: 192: 28.13
+	Hs
		383888 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		383896 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		1070989 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		338748 EGFR_HUMAN (16-1253): 0: 1070: 48.40		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		304961 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		1071007 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		DUS16_HUMAN (7-186): 2.52e-56: 191: 27.22
+	Hs
		1070972 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		DUS6_HUMAN (16-188): 4.93e-57: 186: 29.89
+	Hs
		1070986 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		1070988 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		1071012 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		DUS21_HUMAN (19-185): 6.37e-55: 175: 26.95
+	Hs
		304901 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		338767 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SSH1_HUMAN (10-201): 8.62e-56: 192: 28.13
+	Hs
		338715 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		338145 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DUS3_HUMAN (3-182): 2.87e-57: 181: 27.57
+	Hs
		338743 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		304917 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		601951 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		601936 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		DUS29_HUMAN (22-174): 2.63e-56: 180: 30.77