HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: RIN2 (Q8WYP3)
Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)
Gene: RIN2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 895
+	Hs
		383793 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (37-218): 4.85e-50: 187: 19.79
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (37-218): 1.12e-38: 153: 17.65
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (48-209): 1.23e-36: 147: 18.02
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		383853 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS3_HUMAN (77-223): 2.71e-34: 144: 21.95
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (37-218): 5.74e-36: 145: 19.79
+	Hs
		383987 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS1_HUMAN (72-199): 2.01e-29: 128: 19.44
+	Hs
		383851 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS2_HUMAN (85-199): 1.17e-25: 116: 21.71
+	Hs
		383977 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SLAP2_HUMAN (97-195): 4.73e-23: 101: 27.18
+	Hs
		412202 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		FYN_HUMAN (37-218): 4.85e-50: 187: 19.79
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (37-218): 8.82e-36: 145: 19.79
+	Rn
		1351588 Q9QX70_RAT (21-1254): 0: 1116: 48.96		SRC_RAT (37-218): 5.74e-36: 145: 19.79
+	Hs
		433359 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Rn
		94037 Q9QX70_RAT (21-1254): 0: 1116: 48.96		F1LN91_RAT (77-223): 1.12e-33: 142: 21.34
+	Hs
		454834 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		FGR_HUMAN (37-218): 1.12e-38: 153: 17.65
+	Hs
		846473 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		BLK_HUMAN (48-209): 1.23e-36: 147: 18.02
+	Hs
		522997 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		1070974 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		TENS2_HUMAN (85-199): 1.17e-25: 116: 21.71