HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0030971 - receptor tyrosine kinase binding GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 594
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		383859 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC4_HUMAN (1-593): 1.37e-158: 469: 43.61
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (47-593): 4.99e-147: 438: 43.96
+	Hs
		383867 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1B_HUMAN (11-331): 1.49e-69: 246: 17.68
+	Hs
		275523 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BCAR3_HUMAN (342-592): 6.06e-51: 190: 21.13
+	Hs
		145964 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2B2_HUMAN (302-594): 1.16e-49: 184: 20.07
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (424-594): 2.65e-47: 179: 25.43
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (359-594): 1.87e-47: 175: 18.22
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (342-592): 8.81e-45: 173: 15.91
+	Hs
		383862 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2D5_HUMAN (225-594): 7.49e-47: 171: 15.53
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		383823 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHB_HUMAN (363-590): 9.97e-43: 162: 22.36
+	Hs
		383882 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2D3_HUMAN (371-592): 3.62e-41: 161: 19.16
+	Hs
		383533 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FES_HUMAN (431-594): 4.92e-36: 146: 22.56
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		383587 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK1_HUMAN (478-586): 2.54e-13: 73.7: 24.56