HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: LRCH3 (Q96II8)
DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)
Gene: LRCH3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	34591642
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, CH~PK_Tyr_Ser-Thr, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 777
+	Hs
		383940 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LRRC7_HUMAN (39-434): 3.12e-50: 193: 19.85
+	Hs
		383981 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LRC40_HUMAN (48-289): 2.57e-29: 126: 19.81
+	Mm
		936772 ERBB2_MOUSE (1-1255): 0: 1260: 87.66		ERBIN_MOUSE (170-388): 1.08e-15: 83.7: 20.17
+	Hs
		1071001 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		LRRC7_HUMAN (39-434): 3.12e-50: 193: 19.85
+	Hs
		601980 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		LRRC7_HUMAN (39-434): 3.12e-50: 193: 19.85
+	Hs
		1071006 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		LRRC1_HUMAN (94-325): 2.87e-32: 134: 25.31
+	Hs
		338993 EGFR_HUMAN (16-1253): 0: 1070: 48.40		LRC40_HUMAN (48-289): 2.57e-29: 126: 19.81
+	At
		83729 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		CLV1_ARATH (222-671): 3.08e-52: 198: 10.29
+	At
		83709 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		BAME3_ARATH (13-398): 5.41e-47: 182: 15.54
+	At
		83893 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		BAME3_ARATH (13-398): 5.41e-47: 182: 15.54
+	At
		83724 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		PXC2_ARATH (23-255): 2.29e-41: 165: 22.51
+	At
		83910 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		PXC2_ARATH (23-255): 2.29e-41: 165: 22.51
+	At
		83707 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		BAME1_ARATH (1-151): 1.56e-19: 96: 23.53
+	At
		83892 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		BAME1_ARATH (1-151): 1.56e-19: 96: 23.53
+	At
		83908 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		Y5639_ARATH (466-680): 4.5e-17: 88.3: 7.66
+	At
		83909 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		EMS1_ARATH (427-606): 8.79e-17: 87.1: 11.60
+	At
		83704 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		Y4361_ARATH (461-641): 8.16e-12: 71.3: 9.52
+	At
		83702 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		RGI3_ARATH (507-679): 1.68e-11: 70.2: 7.14
+	At
		83731 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		Q9XGZ2_ARATH (17-150): 7.94e-11: 67.8: 22.06
+	At
		83888 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		RGI3_ARATH (507-679): 1.68e-11: 70.2: 7.14