Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2
Interactor 2: ERBIN (Q96RT1)
Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)
Gene: ERBIN
Species: Homo sapiens
Source: innatedb
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 1.00 | 0.965 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 12444095, 25288731, 11278603, 10878805, 22564389, 12379659, 18316330 |
| Identification Methods | x-ray crystallography, affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation |
| Interaction Type | association, physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr |
| Common GO terms | GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0009925 - basal plasma membrane and 2 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
