HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PTN18 (Q99952)
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
Gene: PTPN18

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.761

Property	Details
Experiments	25081058
Identification Methods	anti tag coimmunoprecipitation, pull down, x-ray crystallography, phosphatase assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 460
+	Hs
		384039 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN22_HUMAN (6-389): 2.21e-146: 439: 38.70
+	Hs
		383836 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRO_HUMAN (4-309): 5.69e-133: 414: 30.23
+	Hs
		383611 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRB_HUMAN (5-315): 1.47e-127: 409: 31.66
+	Hs
		383760 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN12_HUMAN (4-413): 2.43e-135: 409: 35.73
+	Hs
		383633 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN6_HUMAN (5-325): 7.54e-131: 392: 32.95
+	Hs
		383597 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRA_HUMAN (4-307): 3.85e-109: 342: 32.79
+	Hs
		383545 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRC_HUMAN (4-362): 2.82e-80: 272: 24.31
+	Mm
		728828 EGFR_MOUSE (17-1254): 0: 1126: 48.48		PTN12_MOUSE (4-421): 2.75e-134: 407: 35.55
+	Hs
		146920 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRT_HUMAN (22-294): 8.09e-63: 222: 27.76
+	Hs
		383818 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRK_HUMAN (9-295): 9.98e-62: 219: 26.10
+	Hs
		665895 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN6_HUMAN (5-325): 7.54e-131: 392: 32.95
+	Hs
		383612 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRG_HUMAN (4-316): 2.2e-57: 206: 24.77
+	Hs
		383613 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRZ_HUMAN (25-315): 2.81e-56: 203: 26.82
+	Hs
		383622 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN3_HUMAN (54-292): 1.82e-46: 174: 40.16
+	Hs
		383771 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRJ_HUMAN (50-313): 1.3e-44: 169: 38.04
+	Hs
		383762 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN11_HUMAN (51-297): 6.26e-45: 167: 38.70
+	Hs
		146927 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTPRT_HUMAN (22-294): 8.09e-63: 222: 27.76
+	Rn
		1143998 ERBB4_RAT (1-1237): 0: 1101: 45.47		PTPRZ_RAT (5-315): 3.96e-55: 200: 26.09
+	Mm
		719299 EGFR_MOUSE (17-1254): 0: 1126: 48.48		PTN11_MOUSE (51-297): 6.26e-45: 167: 38.70
+	Hs
		719339 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN7_HUMAN (54-301): 1.67e-42: 155: 37.45