HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SH23A (Q9BRG2)
SH2 domain-containing protein 3A (Novel SH2-containing protein 1)
Gene: SH2D3A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 576
+	Hs
		275523 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BCAR3_HUMAN (8-574): 0: 570: 35.42
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (2-256): 7.01e-69: 233: 14.18
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (3-256): 1.73e-68: 232: 13.76
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (3-256): 8.44e-68: 231: 12.36
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (3-256): 7.28e-68: 231: 12.36
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (3-256): 5.16e-66: 225: 11.61
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (3-256): 5.43e-62: 215: 13.48
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (3-256): 1.89e-59: 207: 14.23
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (3-256): 3.11e-58: 204: 14.66
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (3-256): 1.71e-52: 195: 17.18
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (3-256): 8.1e-51: 190: 16.79
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (3-228): 4.74e-49: 181: 14.75
+	Hs
		383672 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TXK_HUMAN (3-228): 1.08e-48: 179: 14.75
+	Hs
		383684 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRK_HUMAN (3-246): 6.1e-51: 179: 21.17
+	Hs
		383685 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRKL_HUMAN (7-246): 6.07e-48: 171: 16.17
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (7-114): 1.92e-36: 147: 31.48
+	Hs
		383601 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG1_HUMAN (2-254): 6.27e-34: 139: 18.42
+	Hs
		383533 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FES_HUMAN (3-114): 4.77e-32: 133: 34.82
+	Hs
		275161 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRAP2_HUMAN (3-149): 8.33e-34: 132: 29.94
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (1-117): 5.09e-32: 132: 32.26