HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 261
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (6-259): 4.1e-79: 249: 30.92
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (33-259): 1.87e-78: 248: 32.34
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (2-259): 4.45e-77: 243: 30.88
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (13-259): 5.35e-77: 244: 31.37
+	Hs
		383767 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ITK_HUMAN (8-260): 7.03e-64: 211: 22.56
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (7-260): 1.36e-62: 208: 21.81
+	Hs
		383672 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TXK_HUMAN (1-260): 3.18e-63: 208: 24.72
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (11-260): 3.92e-58: 201: 22.09
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (18-240): 5.46e-60: 198: 27.54
+	Hs
		383777 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SLAP1_HUMAN (13-259): 4.83e-60: 193: 38.49
+	Hs
		383794 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTK6_HUMAN (26-251): 9.18e-58: 192: 22.88
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (13-259): 1.04e-76: 243: 31.37
+	Hs
		275161 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39