HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: LRC40 (Q9H9A6)
Leucine-rich repeat-containing protein 40
Gene: LRRC40

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 602
+	Hs
		383940 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LRRC7_HUMAN (84-237): 4.82e-16: 84.3: 35.07
+	Hs
		383943 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ERBIN_HUMAN (83-237): 3.33e-14: 78.2: 31.61
+	Mm
		936772 ERBB2_MOUSE (1-1255): 0: 1260: 87.66		ERBIN_MOUSE (198-578): 7.52e-14: 77: 24.48
+	Hs
		338993 EGFR_HUMAN (16-1253): 0: 1070: 48.40		LRC40_HUMAN (1-256): 1.44e-25: 113: 21.45
+	Hs
		1071001 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		LRRC7_HUMAN (84-237): 4.82e-16: 84.3: 35.07
+	Hs
		232756 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PHLP1_HUMAN (82-555): 7.84e-25: 112: 25.00
+	Hs
		1071006 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		LRRC1_HUMAN (41-220): 2.84e-14: 77.8: 31.11
+	Hs
		338869 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ERBIN_HUMAN (83-237): 3.33e-14: 78.2: 31.61
+	Hs
		601980 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		LRRC7_HUMAN (84-237): 4.82e-16: 84.3: 35.07
+	At
		83908 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		Y5639_ARATH (8-598): 4.29e-81: 277: 21.23
+	At
		83704 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		Y4361_ARATH (6-261): 7.37e-35: 143: 20.95
+	At
		83707 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		BAME1_ARATH (14-265): 2.92e-34: 141: 21.62
+	At
		83892 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		BAME1_ARATH (14-265): 2.92e-34: 141: 21.62
+	At
		83702 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		RGI3_ARATH (1-256): 1.6e-32: 135: 22.26
+	At
		83888 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		RGI3_ARATH (1-256): 1.6e-32: 135: 22.26
+	At
		83724 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		PXC2_ARATH (127-575): 1.65e-25: 114: 30.94
+	At
		83729 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		CLV1_ARATH (336-600): 3.79e-24: 109: 16.95
+	At
		83909 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		EMS1_ARATH (485-598): 6.53e-21: 99.6: 22.03
+	At
		83709 Y5182_ARATH (368-1011): 5.07e-140: 450: 15.53		BAME3_ARATH (332-601): 1.66e-15: 82.3: 17.69
+	At
		83893 Y1677_ARATH (372-1026): 5.45e-138: 445: 15.72		BAME3_ARATH (332-601): 1.66e-15: 82.3: 17.69