HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: TENS1 (Q9HBL0)
Tensin-1 (EC 3.1.3.-)
Gene: TNS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1839
+	Hs
		1071015 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		TENS1_HUMAN (1-1839): 0: 831: 100.00
+	Hs
		383853 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS3_HUMAN (700-1838): 4.41e-84: 307: 26.22
+	Hs
		383851 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TENS2_HUMAN (858-1837): 2.37e-64: 244: 25.86
+	Hs
		383583 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MUC1_HUMAN (678-1709): 3.47e-47: 188: 9.93
+	Hs
		338213 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTEN_HUMAN (116-476): 2.2e-117: 379: 27.14
+	Hs
		383977 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SLAP2_HUMAN (1519-1727): 1.63e-39: 150: 20.93
+	Rn
		94037 Q9QX70_RAT (21-1254): 0: 1116: 48.96		F1LN91_RAT (777-1838): 2.61e-80: 295: 25.35
+	Hs
		1070975 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		TENS3_HUMAN (700-1838): 4.41e-84: 307: 26.22
+	Hs
		338552 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TENS3_HUMAN (700-1838): 4.41e-84: 307: 26.22
+	Hs
		383946 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MUC4_HUMAN (811-1748): 2.55e-13: 78.1: 10.14
+	Hs
		1070974 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		TENS2_HUMAN (858-1837): 2.37e-64: 244: 25.86
+	Hs
		338550 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TENS2_HUMAN (858-1837): 2.37e-64: 244: 25.86
+	Hs
		1070981 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		TENS4_HUMAN (1124-1837): 3.08e-52: 199: 27.12
+	Hs
		554307 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC1_HUMAN (678-1709): 3.47e-47: 188: 9.93
+	Hs
		338683 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TENS4_HUMAN (1124-1837): 3.08e-52: 199: 27.12
+	Hs
		337875 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC1_HUMAN (678-1709): 3.47e-47: 188: 9.93
+	Hs
		1071013 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		SLAP2_HUMAN (1519-1727): 1.63e-39: 150: 20.93
+	Hs
		338983 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SLAP2_HUMAN (1519-1727): 1.63e-39: 150: 20.93
+	Hs
		1071005 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		MUC4_HUMAN (811-1748): 2.55e-13: 78.1: 10.14
+	Hs
		338878 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MUC4_HUMAN (811-1748): 2.55e-13: 78.1: 10.14