HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: S10AE (Q9HCY8)
Protein S100-A14 (S100 calcium-binding protein A14) (S114)
Gene: S100A14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 104
+	Hs
		383643 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		S10AB_HUMAN (16-96): 1.36e-26: 96.1: 27.06
+	Hs
		383930 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		S10AG_HUMAN (12-92): 1.93e-24: 90.3: 23.26
+	Hs
		685170 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		S10AB_HUMAN (16-96): 1.36e-26: 96.1: 27.06
+	Hs
		893799 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		S10AA_HUMAN (16-95): 4.45e-26: 94.5: 28.92
+	Hs
		642945 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		S10A4_HUMAN (17-97): 2.93e-24: 89.9: 27.06
+	Hs
		338660 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HORN_HUMAN (15-95): 2.28e-27: 106: 17.65
+	Hs
		338011 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10AB_HUMAN (16-96): 1.36e-26: 96.1: 27.06
+	Hs
		337773 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10A9_HUMAN (14-104): 5.38e-26: 94.5: 30.00
+	Hs
		338220 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10AA_HUMAN (16-95): 4.45e-26: 94.5: 28.92
+	Hs
		337962 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10A4_HUMAN (17-97): 2.93e-24: 89.9: 27.06
+	Hs
		338001 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10A7_HUMAN (16-101): 4e-16: 69.1: 19.15
+	Hs
		601869 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		S10AA_HUMAN (16-95): 4.45e-26: 94.5: 28.92
+	Hs
		601812 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		S10A4_HUMAN (17-97): 2.93e-24: 89.9: 27.06
+	Hs
		380734 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		S100B_HUMAN (15-97): 6.66e-24: 88.8: 27.59
+	Hs
		416337 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		S10A9_HUMAN (14-104): 5.38e-26: 94.5: 30.00
+	Hs
		380737 JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47		S100B_HUMAN (15-97): 6.66e-24: 88.8: 27.59
+	Hs
		616818 JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47		FILA2_HUMAN (15-95): 5.21e-21: 88: 22.35
+	Hs
		396674 INSRR_HUMAN (359-644): 8.09e-16: 85.2: 19.27		S10A8_HUMAN (15-98): 5.64e-23: 86.5: 21.59