HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 389
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (6-256): 4.43e-48: 176: 15.77
+	Hs
		383927 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		Q96D37_HUMAN (6-256): 3.29e-48: 176: 15.77
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		383705 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV2_HUMAN (6-258): 3.29e-46: 171: 13.22
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (5-280): 5.38e-50: 177: 17.45
+	Hs
		383685 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		383684 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		275161 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66
+	Hs
		383935 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HSH2D_HUMAN (76-257): 5.81e-43: 154: 31.32
+	Hs
		383794 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93
+	Hs
		383682 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Hs
		383681 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ZAP70_HUMAN (86-222): 1.53e-17: 86.1: 20.98
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73