HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 756
+	Hs
		145964 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2B2_HUMAN (25-755): 5.52e-128: 396: 35.11
+	Hs
		383805 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB14_HUMAN (76-627): 1.9e-115: 361: 14.19
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (52-627): 2.87e-100: 322: 17.54
+	Hs
		383780 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB10_HUMAN (82-618): 1.38e-92: 302: 12.05
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (40-685): 2.92e-87: 295: 13.46
+	Hs
		383806 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB7_HUMAN (99-613): 1.08e-80: 269: 12.89
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (94-629): 5.86e-77: 261: 15.22
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (356-742): 4.3e-76: 257: 14.25
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (401-742): 2.99e-74: 252: 13.87
+	Hs
		383601 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (378-742): 6.58e-73: 248: 15.57
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (376-742): 1.26e-71: 245: 13.88
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (401-742): 5.95e-70: 240: 14.75
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (435-742): 9.33e-67: 231: 17.13
+	Hs
		383591 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG2_HUMAN (507-753): 4.8e-47: 183: 17.11
+	Hs
		383704 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BMX_HUMAN (320-637): 1.51e-46: 178: 15.75
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (514-607): 2.67e-35: 141: 29.79
+	Hs
		383670 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MATK_HUMAN (439-604): 3.53e-23: 105: 21.18
+	Hs
		383682 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		KSYK_HUMAN (526-637): 4.25e-17: 87.5: 23.01
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46