HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: DJB12 (Q9NXW2)
DnaJ homolog subfamily B member 12
Gene: DNAJB12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 375
+	Hs
		339049 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DJB12_HUMAN (1-375): 1.18e-140: 406: 100.00
+	Hs
		383929 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DNJA3_HUMAN (102-261): 2.09e-43: 158: 32.30
+	Hs
		257881 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DNJB6_HUMAN (110-215): 1.44e-43: 155: 47.71
+	Hs
		383889 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DNJB8_HUMAN (110-249): 2.46e-42: 149: 36.11
+	Hs
		384016 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66
+	Hs
		338830 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DNJA3_HUMAN (102-261): 2.09e-43: 158: 32.30
+	Hs
		339080 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66
+	Hs
		602017 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66
+	Hs
		238430 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		DNJA3_HUMAN (102-261): 2.09e-43: 158: 32.30
+	Mm
		1142038 MUSK_MOUSE (495-984): 5.85e-121: 398: 25.65		DNJA3_MOUSE (85-261): 5.32e-43: 157: 29.78
+	Hs
		411518 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		SEC63_HUMAN (87-373): 4.84e-51: 183: 19.27
+	Hs
		411469 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		DNJA3_HUMAN (102-261): 2.09e-43: 158: 32.30
+	Hs
		434302 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66
+	Hs
		435780 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DJB12_HUMAN (1-375): 1.18e-140: 406: 100.00
+	Hs
		169212 MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66
+	Hs
		411515 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66
+	Hs
		435794 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		SEC63_HUMAN (87-373): 4.84e-51: 183: 19.27
+	Hs
		435729 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DNJA3_HUMAN (102-261): 2.09e-43: 158: 32.30
+	Hs
		435789 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DNJB9_HUMAN (85-247): 2.18e-42: 149: 31.29
+	Hs
		435790 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DJB11_HUMAN (109-189): 1.2e-18: 88.2: 53.66