HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: DJB11 (Q9UBS4)
DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)
Gene: DNAJB11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 358
+	Hs
		383639 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DNJA1_HUMAN (20-356): 3.06e-116: 344: 31.88
+	Hs
		243250 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		DNJA2_HUMAN (21-349): 3.9e-113: 336: 34.35
+	Hs
		339080 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		602017 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		338003 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DNJA1_HUMAN (20-356): 3.06e-116: 344: 31.88
+	Hs
		243241 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DNJA2_HUMAN (21-349): 3.9e-113: 336: 34.35
+	Hs
		601821 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		DNJA1_HUMAN (20-356): 3.06e-116: 344: 31.88
+	Hs
		434302 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		169212 MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		411515 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		243261 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		DNJA2_HUMAN (21-349): 3.9e-113: 336: 34.35
+	Hs
		411313 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		DNJA1_HUMAN (20-356): 3.06e-116: 344: 31.88
+	Hs
		243254 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		DNJA2_HUMAN (21-349): 3.9e-113: 336: 34.35
+	Hs
		435790 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		537779 INSRR_HUMAN (359-644): 8.09e-16: 85.2: 19.27		DJB11_HUMAN (1-358): 1.83e-141: 407: 100.00
+	Hs
		435551 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DNJA1_HUMAN (20-356): 3.06e-116: 344: 31.88
+	Hs
		243262 IGF1R_HUMAN (337-633): 4.59e-20: 99.1: 22.92		DNJA2_HUMAN (21-349): 3.9e-113: 336: 34.35