HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: JIP1 (Q9UQF2)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: MAPK8IP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.828

Property	Details
Experiments	31980649, 16273093, unassigned2173
Identification Methods	two hybrid, unspecified method, ubiquitin reconstruction, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 711
+	Hs
		383867 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1B_HUMAN (424-700): 7.53e-71: 253: 18.60
+	Hs
		383782 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Hs
		383859 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC4_HUMAN (417-711): 6.06e-68: 236: 14.33
+	Hs
		383908 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ANS1A_HUMAN (424-700): 4.74e-64: 232: 18.64
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		383905 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC3_HUMAN (533-706): 5.98e-31: 130: 18.81
+	Mm
		936768 ERBB2_MOUSE (1-1255): 0: 1260: 87.66		SHC1_MOUSE (417-700): 2.09e-34: 140: 16.72
+	Hs
		1070979 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1B_HUMAN (424-700): 7.53e-71: 253: 18.60
+	Hs
		1070976 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		SHC4_HUMAN (417-711): 6.06e-68: 236: 14.33
+	Hs
		1070992 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ANS1A_HUMAN (424-700): 4.74e-64: 232: 18.64
+	Hs
		338632 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ANS1B_HUMAN (424-700): 7.53e-71: 253: 18.60
+	Hs
		338374 EGFR_HUMAN (16-1253): 0: 1070: 48.40		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Hs
		338577 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SHC4_HUMAN (417-711): 6.06e-68: 236: 14.33
+	Mm
		957227 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SHC1_MOUSE (417-700): 2.09e-34: 140: 16.72
+	Rn
		1129188 Q9QX70_RAT (21-1254): 0: 1116: 48.96		SHC1_RAT (540-700): 6.6e-32: 131: 15.76
+	Hs
		666116 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		1070990 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		SHC3_HUMAN (533-706): 5.98e-31: 130: 18.81
+	Hs
		338128 EGFR_HUMAN (16-1253): 0: 1070: 48.40		NUMB_HUMAN (548-704): 2.36e-36: 147: 18.41
+	Hs
		337988 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SHC1_HUMAN (417-700): 6.37e-34: 139: 17.04
+	Hs
		338774 EGFR_HUMAN (16-1253): 0: 1070: 48.40		SHC3_HUMAN (533-706): 5.98e-31: 130: 18.81