HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 575
+	Hs
		145964 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SH2B2_HUMAN (25-573): 1.06e-116: 361: 31.30
+	Hs
		383705 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV2_HUMAN (217-544): 2.36e-56: 205: 11.77
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (192-573): 3.94e-49: 184: 11.77
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Hs
		383805 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB14_HUMAN (196-450): 9.19e-45: 168: 17.94
+	Hs
		383730 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		383685 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CRKL_HUMAN (364-541): 1.25e-41: 154: 22.35
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (245-465): 2.17e-37: 149: 19.56
+	Hs
		383587 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK1_HUMAN (286-446): 2.61e-38: 147: 18.39
+	Hs
		383905 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC3_HUMAN (290-466): 4.39e-37: 147: 22.60
+	Hs
		208972 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NCK2_HUMAN (237-453): 3.16e-38: 146: 16.07
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (354-444): 2.06e-32: 131: 29.67
+	Hs
		383740 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC2_HUMAN (290-469): 3.78e-31: 129: 24.47
+	Hs
		383634 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		383682 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		KSYK_HUMAN (363-573): 4.78e-25: 111: 15.57
+	Hs
		383859 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SHC4_HUMAN (307-468): 2.5e-24: 109: 24.26
+	Hs
		383670 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MATK_HUMAN (343-444): 6e-22: 101: 32.35
+	Hs
		383601 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		129159 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38