HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PIN4 (Q9Y237)
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4)
Gene: PIN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 131
+	Hs
		383786 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PIN1_HUMAN (5-129): 3.73e-37: 125: 27.03
+	Hs
		1071030 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PIN4_HUMAN (1-131): 2.25e-48: 153: 100.00
+	Hs
		339158 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PIN4_HUMAN (1-131): 2.25e-48: 153: 100.00
+	Hs
		602031 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		PIN4_HUMAN (1-131): 2.25e-48: 153: 100.00