HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 807
+	Hs
		383760 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Hs
		983487 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Mm
		728828 EGFR_MOUSE (17-1254): 0: 1126: 48.48		PTN12_MOUSE (1-696): 0: 692: 35.36
+	Hs
		383633 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		383950 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN18_HUMAN (5-329): 1.57e-133: 406: 42.81
+	Hs
		383611 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		383597 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRA_HUMAN (29-290): 2.44e-104: 341: 36.33
+	Hs
		665895 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		146920 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRT_HUMAN (20-292): 1.79e-62: 231: 26.69
+	Hs
		383818 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRK_HUMAN (20-292): 9.08e-61: 225: 30.96
+	Hs
		383910 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRU_HUMAN (20-295): 8.8e-60: 223: 25.80
+	Hs
		383612 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		383613 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRZ_HUMAN (30-323): 4.58e-51: 196: 24.43
+	Hs
		383771 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		383836 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Hs
		383762 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09
+	Hs
		383545 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24
+	Hs
		146927 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTPRT_HUMAN (20-292): 1.79e-62: 231: 26.69
+	Rn
		1143998 ERBB4_RAT (1-1237): 0: 1101: 45.47		PTPRZ_RAT (30-323): 4.5e-50: 193: 24.10
+	Mm
		719299 EGFR_MOUSE (17-1254): 0: 1126: 48.48		PTN11_MOUSE (287-497): 2.12e-12: 72.5: 14.09