HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 999
+	Hs
		320789 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		383646 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		339190 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		338778 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320783 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		338020 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		383840 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		Q53FC7_HUMAN (682-813): 3.1e-27: 120: 20.46
+	Hs
		434320 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		665690 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1072565 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		338019 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HS71L_HUMAN (682-814): 9.92e-31: 131: 15.04
+	Hs
		338520 EGFR_HUMAN (16-1253): 0: 1070: 48.40		Q59EJ3_HUMAN (682-813): 1.16e-30: 131: 16.67
+	Hs
		337839 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		338516 EGFR_HUMAN (16-1253): 0: 1070: 48.40		Q53GZ6_HUMAN (682-815): 2.34e-30: 130: 16.42
+	Hs
		337827 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HS71A_HUMAN (682-813): 3.35e-30: 129: 16.67
+	Hs
		338182 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HSP72_HUMAN (682-814): 8.57e-30: 128: 16.54
+	Hs
		338514 EGFR_HUMAN (16-1253): 0: 1070: 48.40		Q53FC7_HUMAN (682-813): 3.1e-27: 120: 20.46
+	Hs
		503428 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		238339 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		503499 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42