HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 25921289
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_8~PK_Tyr_Ser-Thr, LRR_8~SH2, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0006468 - protein phosphorylation
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 796
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Last updated: 15 Jul 2024