HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 645
+	Hs
		507820 FGFR1_HUMAN (195-794): 0: 545: 26.34		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		531844 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		531720 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		434126 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		435520 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		411285 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PDIA4_HUMAN (1-645): 0: 571: 100.00
+	Hs
		385136 NTRK1_HUMAN (1-796): 0: 621: 100.00		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		384104 NTRK1_HUMAN (1-796): 0: 621: 100.00		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		384875 NTRK1_HUMAN (1-796): 0: 621: 100.00		PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51
+	Hs
		384339 NTRK1_HUMAN (1-796): 0: 621: 100.00		PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35
+	Hs
		385177 NTRK1_HUMAN (1-796): 0: 621: 100.00		TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48
+	Hs
		1081525 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		423118 FGFR1_HUMAN (195-794): 0: 545: 26.34		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		1067715 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51
+	Hs
		607891 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35
+	Hs
		435692 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		411430 INSR_HUMAN (493-777): 3e-68: 248: 42.62		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		423108 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		411271 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		411391 INSR_HUMAN (493-777): 3e-68: 248: 42.62		PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51