HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 397
+	Hs
		243251 NTRK1_HUMAN (1-796): 0: 621: 100.00		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		507875 FGFR1_HUMAN (195-794): 0: 545: 26.34		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		681463 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		243277 FGFR1_HUMAN (195-794): 0: 545: 26.34		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		385330 NTRK1_HUMAN (1-796): 0: 621: 100.00		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		384289 NTRK1_HUMAN (1-796): 0: 621: 100.00		DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59
+	Hs
		243425 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		243293 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		508145 FGFR1_HUMAN (195-794): 0: 545: 26.34		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		507864 FGFR1_HUMAN (195-794): 0: 545: 26.34		DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59
+	Hs
		1081563 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		608081 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		609471 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		243261 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		385658 NTRK1_HUMAN (1-796): 0: 621: 100.00		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		435551 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		1081636 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		243262 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		608166 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		434302 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15