HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: ECHA (P40939)
Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
Gene: HADHA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009410 - response to xenobiotic stimulus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 763
+	Hs
		507896 FGFR1_HUMAN (195-794): 0: 545: 26.34		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778161 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		607904 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		601476 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		609198 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778086 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		435569 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778166 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778331 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		384922 NTRK1_HUMAN (1-796): 0: 621: 100.00		HCDH_HUMAN (361-640): 4.08e-120: 365: 32.99
+	Rn
		431429 INSR_RAT (493-777): 7.31e-66: 241: 41.95		ECHP_RAT (43-763): 0: 740: 28.69
+	Hs
		384338 NTRK1_HUMAN (1-796): 0: 621: 100.00		ECHM_HUMAN (1-292): 1.26e-79: 258: 24.83
+	Hs
		384748 NTRK1_HUMAN (1-796): 0: 621: 100.00		ECH1_HUMAN (52-221): 1.22e-14: 77.8: 31.87