HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.80	0.687

Property	Details
Experiments	25921289, 19167335
Identification Methods	affinity chromatography technology, phosphatase assay
Interaction Type	physical association, dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 780
+	Hs
		384127 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		385757 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Hs
		384278 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		384330 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		384228 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		384697 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		384443 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN9_HUMAN (3-306): 5.55e-124: 385: 31.98
+	Hs
		384777 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		384155 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Hs
		507839 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		507959 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		573718 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		985963 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		573716 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		985962 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		507980 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		1031989 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		384279 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		384920 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		384743 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13