HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: AP3B2 (Q13367)
AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)
Gene: AP3B2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 1082
+	Hs
		119906 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP3B1_HUMAN (2-1082): 0: 909: 59.40
+	Hs
		384621 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP2B1_HUMAN (27-965): 0: 639: 20.79
+	Hs
		384728 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP1B1_HUMAN (27-943): 0: 615: 20.76
+	Hs
		507940 FGFR1_HUMAN (195-794): 0: 545: 26.34		AP2B1_HUMAN (27-965): 0: 639: 20.79
+	Hs
		321460 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP2A1_HUMAN (7-956): 9.81e-173: 534: 11.28
+	Hs
		385654 NTRK1_HUMAN (1-796): 0: 621: 100.00		COPG2_HUMAN (8-939): 1.4e-171: 527: 11.28
+	Hs
		385808 NTRK1_HUMAN (1-796): 0: 621: 100.00		COPG1_HUMAN (8-939): 2.26e-171: 527: 11.25
+	Hs
		212583 NTRK1_HUMAN (1-796): 0: 621: 100.00		AP1G1_HUMAN (18-818): 3.11e-171: 525: 13.18
+	Hs
		1014018 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		AP1B1_HUMAN (27-943): 0: 615: 20.76
+	Hs
		321475 FGFR1_HUMAN (195-794): 0: 545: 26.34		AP2A1_HUMAN (7-956): 9.81e-173: 534: 11.28
+	Hs
		508297 FGFR1_HUMAN (195-794): 0: 545: 26.34		COPG1_HUMAN (8-939): 2.26e-171: 527: 11.25
+	Hs
		321487 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		AP2A1_HUMAN (7-956): 9.81e-173: 534: 11.28
+	Rn
		102587 INSR_RAT (493-777): 7.31e-66: 241: 41.95		G3V9N8_RAT (27-965): 0: 611: 20.06
+	Hs
		384548 NTRK1_HUMAN (1-796): 0: 621: 100.00		COPB_HUMAN (42-641): 8.95e-54: 206: 17.50
+	Rn
		71352 INSR_RAT (493-777): 7.31e-66: 241: 41.95		B2RYN6_RAT (18-818): 1.63e-169: 521: 13.06
+	Rn
		544838 INSR_RAT (493-777): 7.31e-66: 241: 41.95		COPG1_RAT (8-939): 1.03e-168: 520: 11.25
+	Hs
		507921 FGFR1_HUMAN (195-794): 0: 545: 26.34		COPB_HUMAN (42-641): 8.95e-54: 206: 17.50
+	Hs
		863239 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		COPB_HUMAN (42-641): 8.95e-54: 206: 17.50
+	Hs
		411342 INSR_HUMAN (493-777): 3e-68: 248: 42.62		COPB_HUMAN (42-641): 8.95e-54: 206: 17.50
+	Rn
		544774 INSR_RAT (493-777): 7.31e-66: 241: 41.95		COPB_RAT (42-641): 2.92e-53: 204: 17.66