HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 25921289, 35384245
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~LRR_8, LRR_8~ig, LRR_8~LRR_8, LRRCT_2~LRR_8, LRR_8~LRRNT, LRR_8~PK_Tyr_Ser-Thr, LRRCT_2~ig, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005030 - neurotrophin receptor activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
and 6 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 796
Hs

1 839
+ Hs
+ Rn
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024