HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 551
+	Hs
		385166 NTRK1_HUMAN (1-796): 0: 621: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		384516 NTRK1_HUMAN (1-796): 0: 621: 100.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		384775 NTRK1_HUMAN (1-796): 0: 621: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		302238 NTRK1_HUMAN (1-796): 0: 621: 100.00		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		384175 NTRK1_HUMAN (1-796): 0: 621: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		384961 NTRK1_HUMAN (1-796): 0: 621: 100.00		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18
+	Hs
		384551 NTRK1_HUMAN (1-796): 0: 621: 100.00		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		297846 NTRK1_HUMAN (1-796): 0: 621: 100.00		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Hs
		385629 NTRK1_HUMAN (1-796): 0: 621: 100.00		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76
+	Hs
		302247 FGFR1_HUMAN (195-794): 0: 545: 26.34		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		302291 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		302255 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		508046 FGFR1_HUMAN (195-794): 0: 545: 26.34		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18
+	Hs
		302241 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		302242 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		302332 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Rn
		102464 INSR_RAT (493-777): 7.31e-66: 241: 41.95		G3V699_RAT (120-488): 2.87e-23: 106: 15.14
+	Rn
		88882 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D4A233_RAT (81-386): 3.58e-19: 92.7: 13.19
+	Hs
		435662 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18
+	Hs
		968398 ROR2_HUMAN (515-783): 2.79e-66: 239: 43.91		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18