Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: SORT (Q99523)
Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
Gene: SORT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.60 0.641

The method score is based on:

Property Details
Experiments 25921289, 21102451
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0010008 - endosome membrane
GO:0010465 - nerve growth factor receptor activity
and 2 others

more...

Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 796
Hs

1 831
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024