HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030424 - axon GO:0030425 - dendrite GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 1336
+	Hs
		229615 NTRK1_HUMAN (1-796): 0: 621: 100.00		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		164090 NTRK1_HUMAN (1-796): 0: 621: 100.00		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		164095 FGFR1_HUMAN (195-794): 0: 545: 26.34		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		164126 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		164125 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		164101 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		384385 NTRK1_HUMAN (1-796): 0: 621: 100.00		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		384789 NTRK1_HUMAN (1-796): 0: 621: 100.00		ROCK1_HUMAN (2-581): 2.57e-21: 103: 9.37
+	Hs
		384384 NTRK1_HUMAN (1-796): 0: 621: 100.00		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		384981 NTRK1_HUMAN (1-796): 0: 621: 100.00		MRCKA_HUMAN (2-407): 2.77e-19: 96.9: 12.93
+	Hs
		384210 NTRK1_HUMAN (1-796): 0: 621: 100.00		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		254431 NTRK1_HUMAN (1-796): 0: 621: 100.00		ROCK2_HUMAN (2-348): 1.31e-13: 78.3: 7.20
+	Hs
		385083 NTRK1_HUMAN (1-796): 0: 621: 100.00		KI21A_HUMAN (40-567): 1.66e-13: 78: 9.65
+	Hs
		507982 FGFR1_HUMAN (195-794): 0: 545: 26.34		ROCK1_HUMAN (2-581): 2.57e-21: 103: 9.37
+	Hs
		254442 FGFR1_HUMAN (195-794): 0: 545: 26.34		ROCK2_HUMAN (2-348): 1.31e-13: 78.3: 7.20
+	Hs
		609500 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		164118 ROR2_HUMAN (515-783): 2.79e-66: 239: 43.91		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		665375 EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Rn
		88668 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D3ZN37_RAT (276-702): 7.28e-17: 88.8: 8.67
+	Rn
		89022 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D4AE06_RAT (1-357): 7.01e-14: 79.1: 9.75