HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 2541
+	Hs
		255274 NTRK1_HUMAN (1-796): 0: 621: 100.00		HIP1R_HUMAN (1834-2532): 3.66e-139: 467: 19.78
+	Hs
		124359 NTRK1_HUMAN (1-796): 0: 621: 100.00		HIP1_HUMAN (1798-2532): 2.31e-117: 402: 20.27
+	Hs
		385781 NTRK1_HUMAN (1-796): 0: 621: 100.00		FARP1_HUMAN (52-1026): 1.66e-112: 388: 11.82
+	Hs
		385554 NTRK1_HUMAN (1-796): 0: 621: 100.00		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		508287 FGFR1_HUMAN (195-794): 0: 545: 26.34		FARP1_HUMAN (52-1026): 1.66e-112: 388: 11.82
+	Hs
		384207 NTRK1_HUMAN (1-796): 0: 621: 100.00		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		384378 NTRK1_HUMAN (1-796): 0: 621: 100.00		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		1083898 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		507884 FGFR1_HUMAN (195-794): 0: 545: 26.34		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		719502 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		507828 FGFR1_HUMAN (195-794): 0: 545: 26.34		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		507885 FGFR1_HUMAN (195-794): 0: 545: 26.34		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		719722 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		507865 FGFR1_HUMAN (195-794): 0: 545: 26.34		MOES_HUMAN (163-404): 1.04e-51: 195: 23.05
+	Hs
		384681 NTRK1_HUMAN (1-796): 0: 621: 100.00		DYST_HUMAN (422-2075): 3.73e-15: 84.9: 9.63
+	Hs
		385312 NTRK1_HUMAN (1-796): 0: 621: 100.00		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82
+	Hs
		508011 FGFR1_HUMAN (195-794): 0: 545: 26.34		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52
+	Hs
		508139 FGFR1_HUMAN (195-794): 0: 545: 26.34		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82
+	Hs
		974084 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		DYST_HUMAN (422-2075): 3.73e-15: 84.9: 9.63
+	Hs
		1081562 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82