HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: S23IP (Q9Y6Y8)
SEC23-interacting protein (p125)
Gene: SEC23IP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SAM_1
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1000
+	Hs
		508302 FGFR1_HUMAN (195-794): 0: 545: 26.34		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		1081666 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		608216 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		434326 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		1357284 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		169216 MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		123828 NTRK1_HUMAN (1-796): 0: 621: 100.00		SPT5H_HUMAN (25-328): 9.63e-34: 142: 20.13
+	Hs
		302238 NTRK1_HUMAN (1-796): 0: 621: 100.00		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		385629 NTRK1_HUMAN (1-796): 0: 621: 100.00		OGFR_HUMAN (55-280): 9.14e-11: 68.1: 18.86
+	Hs
		225331 NTRK1_HUMAN (1-796): 0: 621: 100.00		MED14_HUMAN (24-217): 5.47e-10: 65.8: 15.98
+	Hs
		384551 NTRK1_HUMAN (1-796): 0: 621: 100.00		SC24C_HUMAN (33-278): 2.74e-09: 63.5: 17.03
+	Hs
		302247 FGFR1_HUMAN (195-794): 0: 545: 26.34		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		302291 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		302255 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		302241 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		123859 LTK_HUMAN (502-790): 3.09e-60: 221: 41.64		SPT5H_HUMAN (25-328): 9.63e-34: 142: 20.13
+	Hs
		302242 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		302332 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99
+	Hs
		169154 MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61		SC31A_HUMAN (8-309): 1.62e-18: 93.5: 12.99