HitPredict

Interactor 1: S100B (P04631)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Interactor 2: RAGE (Q63495)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: Ager

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19910580
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_2~S_100
Common GO terms	GO:0005615 - extracellular space GO:0007611 - learning or memory GO:0043025 - neuronal cell body GO:0043065 - positive regulation of apoptotic process GO:0044548 - S100 protein binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 92 Rn			1 402
+	Hs
		638960 S100P_HUMAN (1-91): 2.3e-34: 114: 49.45		RAGE_HUMAN (1-402): 1.5e-67: 221: 77.72
+	Hs
		615216 S10A1_HUMAN (2-89): 2.43e-33: 112: 60.23		RAGE_HUMAN (1-402): 1.5e-67: 221: 77.72
+	Hs
		380779 S100B_HUMAN (1-92): 8.27e-32: 108: 97.83		RAGE_HUMAN (1-402): 1.5e-67: 221: 77.72
+	Hs
		642944 S10A4_HUMAN (3-90): 1.5e-30: 105: 48.86		RAGE_HUMAN (1-402): 1.5e-67: 221: 77.72
+	Hs
		946195 S10AC_HUMAN (1-92): 1.18e-29: 102: 36.96		RAGE_HUMAN (1-402): 1.5e-67: 221: 77.72
+	Hs
		793247 S10AA_HUMAN (2-89): 1.73e-29: 102: 37.50		MUC18_HUMAN (24-299): 1.99e-63: 216: 24.32
+	Hs
		639033 S100P_HUMAN (1-91): 2.3e-34: 114: 49.45		PXDN_HUMAN (5-119): 2.89e-15: 80.1: 18.26
+	Hs
		642975 S10A4_HUMAN (3-90): 1.5e-30: 105: 48.86		PXDN_HUMAN (5-119): 2.89e-15: 80.1: 18.26
+	Hs
		661374 S10A2_HUMAN (2-90): 6.88e-30: 103: 44.94		PXDN_HUMAN (5-119): 2.89e-15: 80.1: 18.26