Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.995

The method score is based on:

Property Details
Experiments 19339993, 21231916, 8035799, 22522597, 27462439, 25603536, 24374182, 14580323, 29549180, 17135243, 30503669, 11948396, 28205554, 31152661, 31182485, 32904724, 32807901, 36358651, 36352191, 19011633 and 26 others

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Identification Methods pull down, biochemical, affinity chromatography technology, x-ray crystallography, fluorescent resonance energy transfer, two hybrid, tandem affinity purification, ubiquitin reconstruction, cosedimentation in solution, nuclear magnetic resonance and 10 others

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Interaction Type direct interaction, association, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains P53~P53, P53~P53_tetramer, P53_TAD~TAD2, P53_tetramer~P53_tetramer
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000423 - mitophagy
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
and 168 others

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Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 393
Hs

1 393
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Last updated: 15 Jul 2024