HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

The method score is based on:

Property	Details
Experiments	31152661, 32807901, 17184779, 23443559
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol and 9 others more... GO:0006983 - ER overload response GO:0019899 - enzyme binding GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0042149 - cellular response to glucose starvation GO:0043066 - negative regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051087 - protein-folding chaperone binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	654

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024