HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 0.60 0.729

The method score is based on:

Property Details
Experiments 24554706, 31796886, 11792711, 15933712, 16169070
Identification Methods pull down, affinity chromatography technology, two hybrid, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 10 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 393
Hs

1 181
+ Hs
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024