HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: TF2H1 (P32780)
General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)
Gene: GTF2H1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 7935417, 18160537, 18354501, 8612585, 16793543
Identification Methods pull down, far western blotting, x-ray crystallography, isothermal titration calorimetry, nuclear magnetic resonance
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH_TFIIH~TAD2
Common GO terms GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0006289 - nucleotide-excision repair
GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 393
Hs

1 548
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024