HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

The method score is based on:

Property	Details
Experiments	14523002, 12048243, 21900206, 14744935
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002020 - protease binding GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 9 others more... GO:0005739 - mitochondrion GO:0005813 - centrosome GO:0005829 - cytosol GO:0006983 - ER overload response GO:0010628 - positive regulation of gene expression GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process GO:0043525 - positive regulation of neuron apoptotic process GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	420

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024