HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

The method score is based on:

Property	Details
Experiments	19448667, 33476981, 17666433, 11950834, 21900401, 18303029
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0002039 - p53 binding GO:0003677 - DNA binding GO:0005634 - nucleus and 11 others more... GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0006357 - regulation of transcription by RNA polymerase II GO:0016363 - nuclear matrix GO:0030308 - negative regulation of cell growth GO:0032991 - protein-containing complex GO:0045815 - transcription initiation-coupled chromatin remodeling GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	1647

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024