HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: S10AA (P60903)
Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)
Gene: S100A10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	S_100~TAD2
Common GO terms	GO:0005737 - cytoplasm GO:0016363 - nuclear matrix GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 97
+	Hs
		387043 P53_HUMAN (1-393): 0: 619: 100.00		HORN_HUMAN (1-97): 6.55e-32: 118: 30.69
+	Hs
		386104 P53_HUMAN (1-393): 0: 619: 100.00		S10A1_HUMAN (1-91): 7.71e-34: 113: 45.75
+	Hs
		386185 P53_HUMAN (1-393): 0: 619: 100.00		S10AB_HUMAN (2-89): 4.9e-32: 109: 38.46
+	Hs
		386865 P53_HUMAN (1-393): 0: 619: 100.00		FILA2_HUMAN (3-97): 5.92e-28: 107: 34.34
+	Hs
		386132 P53_HUMAN (1-393): 0: 619: 100.00		S100P_HUMAN (3-87): 5.8e-31: 106: 45.46
+	Hs
		386137 P53_HUMAN (1-393): 0: 619: 100.00		S10A4_HUMAN (1-87): 5.03e-29: 101: 35.56
+	Hs
		386192 P53_HUMAN (1-393): 0: 619: 100.00		S10A3_HUMAN (1-89): 7.96e-29: 101: 27.17
+	Hs
		386155 P53_HUMAN (1-393): 0: 619: 100.00		S10A2_HUMAN (1-87): 6.38e-28: 98.8: 36.67
+	Hs
		380714 P53_HUMAN (1-393): 0: 619: 100.00		S100B_HUMAN (3-87): 2.3e-26: 94.6: 37.50
+	Hs
		387288 P53_HUMAN (1-393): 0: 619: 100.00		S10AG_HUMAN (3-96): 6.44e-26: 93.8: 23.47
+	Hs
		386512 P53_HUMAN (1-393): 0: 619: 100.00		S10AC_HUMAN (3-89): 1.55e-24: 89.9: 31.11
+	Hs
		386191 P53_HUMAN (1-393): 0: 619: 100.00		S10A5_HUMAN (1-92): 1.15e-23: 88: 30.53
+	Hs
		385910 P53_HUMAN (1-393): 0: 619: 100.00		S10A8_HUMAN (1-93): 1.69e-23: 87.6: 25.00
+	Hs
		385924 P53_HUMAN (1-393): 0: 619: 100.00		S10A6_HUMAN (1-88): 2.47e-23: 86.9: 25.28
+	Hs
		387371 P53_HUMAN (1-393): 0: 619: 100.00		S10AD_HUMAN (3-81): 1.23e-18: 75.3: 30.49
+	Hs
		386596 P53_HUMAN (1-393): 0: 619: 100.00		TRHY_HUMAN (3-83): 7.24e-10: 55.7: 32.14